Corticosteroids for treating sepsis.
Cochrane Database Syst Rev. 2015 Dec 4;12:CD002243.

Trial of continuous or interrupted chest compressions during CPR.
N Engl J Med. 2015 Dec 3;373(23):2203-14.

Heliox inhalation therapy for bronchiolitis in infants.
Cochrane Database Syst Rev. 2015 Sep 18;9:CD006915.

Time to epinephrine and survival after pediatric in-hospital cardiac arrest.
JAMA. 2015 Aug 25;314(8):802-10.

Endotracheal intubation versus supraglottic airway placement in out-of-hospital cardiac arrest: A meta-analysis.
Resuscitation. 2015 Aug;93:20-6.

Characterizing degree of lung injury in pediatric acute respiratory distress syndrome.
Crit Care Med. 2015 May;43(5):937-46.

Mechanical versus manual chest compressions for cardiac arrest.
Cochrane Database Syst Rev. 2014 Feb 27;2:CD007260

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children.
Cochrane Database Syst Rev. 2015 Jan 7;1:CD010473.

 

Lower versus higher hemoglobin threshold for transfusion in septic shock.
N Engl J Med 2014; 371:1381-1391

High versus low blood-pressure target in septic shock.
N Engl J Med 2014; 371:1381-1391

A randomized trial of protocol-based care for early septic shock.
N Engl J Med 2014; 370:1683-1693.

Intranasal fentanyl for the management of acute pain in children.
Cochrane Database Syst Rev. 2014 Oct 10;10:CD009942.

Anticonvulsant therapy for status epilepticus.
Cochrane Database Syst Rev. 2014 Sep 10;9:CD003723.

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial.
JAMA. 2014 Apr 23-30;311(16):1652-60.

Inhaled anticholinergics and short-acting beta2-agonists versus short-acting beta2-agonists alone for children with acute asthma in hospital.
Cochrane Database Syst Rev. 2014 Jul 31;7:CD010283.

Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials.
Resuscitation. 2014 Jun;85(6):732-40.

Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry.
BMJ 2014;348:g3028

Nebulized hypertonic saline for bronchiolitis: a randomized clinical trial.
JAMA Pediatr. 2014 Jul 1;168(7):657-63.

Nebulized hypertonic saline for bronchiolitis in the emergency department: a randomized clinical trial.
JAMA Pediatr. 2014 Jul 1;168(7):664-70.

A Randomized Trial of Hyperglycemic Control in Pediatric Intensive Care.
N Engl J Med 2014; 370:107-118.

 

Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial.
Lancet Neurol 2013; 12: 546-553.

Induced hypothermia in severe bacterial meningitis: a randomized clinical trial.
JAMA. 2013 Nov 27;310(20):2174-83.

Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial.
Intensive Care Med (2013) 39:2011–2019.

High-frequency oscillation for acute respiratory distress syndrome.
N Engl J Med 2013; 368:806-813.

High-frequency oscillation in early acute respiratory distress syndrome.
N Engl J Med. 2013 Feb 28;368(9):795-805.

Prone positioning in severe acute respiratory distress syndrome.
N Engl J Med. 2013 Jun 6;368(23):2159-68.

Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense.
Crit Care Med. 2013 Jul;41(7):1774-81.

Colloids versus crystalloids for fluid resuscitation in critically ill patients.
Cochrane Database Syst Rev. 2013 Feb 28;2:CD000567.

Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database.
Crit Care Med. 2013 Mar;41(3):774-83.

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012.
Intensive Care Med (2013) 39:165–228.

 

Drotrecogin Alfa (Activated) in Adults with Septic Shock.
N Engl J Med 2012;366:2055-64.

A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury.
N Engl J Med 2012; 367:2471-2481.

Fatal and Near-Fatal Asthma in Children: The Critical Care Perspective
J Pediatr 2012

Variation in Intracranial Pressure Monitoring and Outcomes in Pediatric Traumatic Brain Injury (TBI)
Arch Pediatr Adolesc Med 2012

A Cost-effectiveness Analysis of Dexamethasone Versus Prednisone in Pediatric Acute Asthma Exacerbations
Acad Emerg Med 2012

Prehospital Epinephrine Use and Survival Among Patients With Out-of-Hospital Cardiac Arrest
JAMA 2012

Yield of Diagnostic Studies in Children Presenting with Complex Febrile Seizures
Pediatr Emerg Care 2012

Capillary Refill Time and Cardiac Output in Children Undergoing Cardiac Catheterization
Pediatr Crit Care Med 2012

Early Administration of Systemic Corticosteroids Reduces Hospital Admission Rates for Children With Moderate and Severe Asthma Exacerbation
Ann Emerg Med 2012

Corticosteroid After Etomidate in Critically Ill Patients: A Randomized Controlled Trial
Crit Care Med 2012

 

Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies
The Lancet, Volume 377, Issue 9770, Pages 1011 - 1018, 19 March 2011

Treatment of Neonatal Sepsis with Intravenous Immune Globulin
N Eng J Med 2011

The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America
Clin Infect Dis. 2011

Mortality After Fluid Bolus in African Children With Severe Infection
N Eng J Med 2011

Early Versus Later Rhythm Analysis in Patients with Out-of-Hospital Cardiac Arrest
N Eng J Med 2011

Amputation and intraosseous access in infants
BMJ 2011

Decompressive Craniectomy in Diffuse Traumatic Brain Injury
N Engl J Med 2011

Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials
Crit Care Med. 2011

Universally poor outcomes of pediatric traumatic arrest: A prospective case series and review of the literature
Pediatr Emerg Care 2011

5 versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: a double-blind randomised equivalence study
Lancet 2011

Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy
Pediatr Crit Care Med 2011

Extracorporeal membrane oxygenation for pediatric respiratory failure: Survival and predictors of mortality
Crit Care Med 2011

 

Pediatric basic and advanced life support: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations
Circulation 2010

Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality
JAMA 2010

Conventional and chest-compression-only cardiopulmonary resuscitation by bystanders for children who have out-of-hospital cardiac arrests: a prospective, nationwide, population-based cohort study
Lancet 2010

Comparison of dopamine and norepinephrine in the treatment of shock
N Engl J Med 2010

Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial
Ann Surg 2010

A prospective multicenter study of adrenal function in critically ill children
Am J Respir Crit Care Med 2010

Diagnosis of ventilator-associated pneumonia in children in resource-limited setting: a comparative study of bronchoscopic and nonbronchoscopic methods
Pediatr Crit Care Med 2010

 

Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study
Lancet 2009

intravenous drug administration during out-of-hospital cardiac arrest
JAMA 2009

intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures
Pediatr Crit Care Med 2009

intensive versus conventional glucose control in critically ill patients
N Eng J Med 2009

intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study
Lancet 2009

Epidemiology and outcomes from out-of-hospital cardiac arrest in children. The resuscitation outcomes consortium epistry–cardiac arrest
Circulation 2009

Hypothermia therapy after pediatric cardiac arrest
Circulation 2009

Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial
Crit Care Med 2009

pediatric procedural sedation by a dedicated nonanesthesiology pediatric sedation service using propofol
Pediatric Emergency Care 2009

The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: A report from the pediatric sedation research consortium
Anesth Analg 2009

Antibiotic-resistant bacteria and infection in children with cerebral palsy requiring mechanical ventilation
Pediatr Crit Care Med 2009

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the american college of critical care medicine
Crit Care Med 2009

influence of vasopressor agent in septic shock mortality. Results from the Portuguese community-acquired sepsis study (SACiUCI study)
Crit Care Med 2009

interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock
Crit Care Med 2009

Neuroendocrine dysfunction in pediatric critical illness
Pediatr Crit Care Med 2009

Arterial blood gases and oxygen content in climbers on Mount Everest
N Eng J Med 2009

Decontamination of the digestive tract and oropharynx in ICU patients
N Eng J Med 2009

Weaning and extubation readiness in pediatric patients
Pediatr Crit Care Med 2009

Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury
Crit Care Med 2009

incidence and risk factors of upper gastrointestinal bleeding in mechanically ventilated children
Pediatr Crit Care Med 2009

Saline instillation before tracheal suctioning decreases the incidence of ventilator-associated pneumonia
Crit Care Med 2009

 

Hypothermia therapy after pediatric cardiac arrest
Circulation 2008

intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical critically ill patients
Crit Care Med 2008

intracranial pressure monitoring in severe isolated pediatric blunt head trauma
Am Surg 2008

The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: A randomized, controlled open study
Pediatr Crit Care Med 2008

Mechanical ventilation guided by esophageal pressure in acute lung injury
N Eng J Med 2008

A prospective randomized controlled study of two fluid Regimens in the initial Management of Septic Shock in the Emergency Department
Pediatr Emerg Care 2008

Distinct Hemodynamic Patterns of Septic Shock at Presentation to Pediatric intensive Care
Pediatrics 2008

Recruitment Maneuvers for Acute Lung injury: A Systematic Review
Am J Respir Crit Care Med 2008

The Endotracheal Tube Air Leak Test does not Predict Extubation Outcome in Critically Ill Pediatric Patients
Pediatr Crit Care Med 2008

A Prospective, Randomized, Controlled Trial of Noninvasive Ventilation in Pediatric Acute Respiratory Failure
Pediatr Crit Care Med 2008

Use of Methylene Blue Spectrophotometry to Detect Subclinical Aspiration in Enterally Fed intubated Pediatric Patients
Pediatr Crit Care Med 2008

Anemia, Blood Loss, and Blood Transfusions in North American Children in the intensive Care Unit
Am J Respir Crit Care Med 2008

intravenous Postoperative Fluid Prescriptions for Children: A Survey of Practice
BMC Surg 2008

intensity of Renal Support in Critically Ill Patients with Acute Kidney injury
N Eng J Med 2008

Hypothermia Therapy after Traumatic Brain injury in Children
N Eng J Med 2008

ACCM/PALS Haemodynamic Support Guidelines for Paediatric Septic Shock: An Outcomes Comparison With and Without Monitoring Central Venous Oxygen Saturation
intensive Care Med 2008

Association between Critical Care Physician Management and Patient Mortality in the intensive Care Unit
Ann intern Med 2008

Calcium Use During in-hospital Pediatric Cardiopulmonary Resuscitation: A Report from the National Registry of Cardiopulmonary Resuscitation
Pediatrics 2008

Children's Factual and Delusional Memories of intensive Care
Am J Respir Crit Care Med 2008

Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients: A Randomized Trial
Am J Respir Crit Care Med 2008

Evolution of Mechanical Ventilation in Response to Clinical Research
Am J Respir Crit Care Med 2008

Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial infarction and Death
JAMA 2008

intracranial Pressure Monitoring in Brain-injured Patients Is Associated with Worsening of Survival
J Trauma 2008

Vasopressin versus Norepinephrine infusion in Patients with Septic Shock
N Eng J Med 2008

Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung injury and Acute Respiratory Distress Syndrome
JAMA 2008

Positive End-Expiratory Pressure Setting in Adults With Acute Lung injury and Acute Respiratory Distress Syndrome
JAMA 2008

Hydrocortisone Therapy for Patients with Septic Shock
N Eng J Med 2008

intensive insulin Therapy and Pentastarch Resuscitation in Severe Sepsis
N Eng J Med 2008

Surviving Sepsis Campaign: international Guidelines for Management of Severe Sepsis and Septic Shock: 2008
Crit Care Med 2008

 

Using Pediatric Advanced Life Support in pediatric residency training: Does the curriculum need resuscitation?
Pediatr Crit Care Med 2007

Propofol Sedation: intensivists' Experience With 7304 Cases in a Children's Hospital
Pediatrics 2007

Rapid Fluid Resuscitation in Pediatrics: Testing the American College of Critical Care Medicine Guideline
Annals
of Emergency Medicine 2007

intravenous and Nebulised Magnesium Sulphate for Acute Asthma: Systematic Review and Meta-analysis
Emergency Medicine Journal 2007

Etomidate versus Pentobarbital for Computed Tomography Sedations: Report from the Pediatric Sedation Research Consortium
Pediatric Emergency Care 2007

Efficacy and Safety of Epoetin Alfa in Critically Ill Patients
N Eng J Med 2007

Saline or Albumin for Fluid Resuscitation in Patients with Traumatic Brain injury
N Eng J Med 2007

Norepinephrine Plus Dobutamine versus Epinephrine Alone for Management of Septic Shock: a Randomised Trial
Lancet 2007

A Multicenter, Randomized, Controlled Trial of Dexamethasone for Bronchiolitis
N Eng J Med 2007

increased Calcium Supplementation Is Associated with Morbidity and Mortality in the infant Postoperative Cardiac Patient
Pediatr Crit Care Med 2007

Transfusion Strategies for Patients in Pediatric intensive Care Units
N Eng J Med 2007

Drotrecogin Alfa (Activated) in Children with Severe Sepsis: a Multicentre Phase III Randomised Controlled Trial
Lancet 2007

Pediatric Procedural Sedation in the Community Emergency Department: Results from the ProSCED Registry
Pediatric Emergency Care 2007

Dexmedetomidine: Applications in Pediatric Critical Care and Pediatric Anesthesiology
Pediatr Crit Care Med 2007

Use of Anesthetic Agents in Neonates and Young Children
Pediatric Anesthesia 2007

Methylprednisolone infusion in Early Severe ARDS Results of a Randomized Controlled Trial
Chest 2007

Safety of Rapid intravenous Valproate infusion in Pediatric Patients
Pediatric Neurology 2007

 

What are the etiology and epidemiology of out-of-hospital pediatric cardiopulmonary arrest in Ontario, Canada?
Acad Emerg Med 2006

Mixed Venous Oxygen Saturation Cannot Be Estimated by Central Venous Oxygen Saturation in Septic Shock
intensive Care Medicine 2006

Agreement Between Arterial and Central Venous Values for pH, Bicarbonate, Base Excess, and Lactate
Emergency Medicine Journal 2006

Does Dopamine Administration in Shock influence Outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study
Crit Care Med 2006

Frequency of Sub-clinical Cerebral Edema in Children With Diabetic Ketoacidosis
Pediatric Diabetes 2006

Sodium Valproate vs Phenytoin in Status Epilepticus: A Pilot Study
Neurology 2006

incidence and Nature of Adverse Events During Pediatric Sedation/Anesthesia for Procedures Outside the Operating Room
Pediatrics 2006

Comparison of Two Fluid-Management Strategies in Acute Lung injury
N Eng J Med 2006

Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung injury
N Eng J Med 2006

Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome
N Eng J Med 2006

intensive insulin Therapy in the Medical ICU
N Eng J Med 2006

 

Cost-effectiveness of training unselected laypersons in cardiopulmonary resuscitation and defibrillation
Am J Med 2005

Clinical Efficacy of Serial Computed Tomographic Scanning in Pediatric Severe Traumatic Brain injury
Pediatric Surgery international 2005

Effect of intracranial Pressure Monitoring and Targeted intensive Care on Functional Outcome After Severe Head injury
Crit Care Med 2005

Effect of Prone Positioning on Clinical Outcomes in Children With Acute Lung injury: A Randomized Controlled Trial
JAMA 2005

Anticonvulsant Therapy for Status Epilepticus
Cochrane Database Syst Rev 2005

Hyperventilation in Severe Diabetic Ketoacidosis
Pediatr Crit Care Med 2005

Adrenal insufficiency in Meningococcal Sepsis: Bioavailable Cortisol Levels and Impact of interleukin-6 Levels and intubation with Etomidate on Adrenal Function and Mortality
The Journal
of Clinical Endocrinology & Metabolism 2005

A Retrospective Cohort Study of Prognostic Factors Associated With Outcome in Pediatric Severe Sepsis: What is the Role of Steroids?
Pediatr Crit Care Med 2005

Effect of Exogenous Surfactant (Calfactant) in Pediatric Acute Lung injury
JAMA 2005

Therapeutic Hypothermia for Head injury
Cochrane Database Syst Rev 2005

 

Advanced Cardiac Life Support in Out-of-Hospital Cardiac Arrest
N Eng J Med 2004

Mechanism of Cerebral Edema in Children with Diabetic Ketoacidosis
J Pediatr 2004

Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock
Crit Care Med 2004

Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
N Eng J Med 2004

Gastric vs Small-Bowel Feeding in Critically Ill Children Receiving Mechanical Ventilation: A Randomized Controlled Trial
Chest 2004

A Comparison of Albumin and Saline for Fluid Resuscitation in the intensive Care Unit
N Eng J Med 2004

A comparison of High-Dose and Standard-Dose Epinephrine in Children with Cardiac Arrest.
N Eng J Med 2004

Noninvasive Positive Pressure Ventilation in Children with Lower Airway Obstruction
Pediatr Crit Care Med 2004

Randomized Controlled Trial of Aerosolized Prostacyclin Therapy in Children with Acute Lung injury
Critical Care 2004

Low inferior Vena Caval Catheters for Hemodynamic and Pulmonary Function Monitoring in Pediatric Critical Care Patients
Pediatr Crit Care Med 2004

 

Relationship of Pulmonary Artery Catheter Use to Mortality and Resource Utilization in Patients with Severe Sepsis
Crit Care Med 2003

Early Use of the Pulmonary Artery Catheter and Outcomes in Patients with Shock and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
JAMA 2003

Deep Sedation With Propofol by Nonanesthesiologists
Arch Pediatr Adolesc Med 2003

Early Reversal of Pediatric-Neonatal Septic Shock by Community Physicians Is Associated With Improved Outcome
Pediatrics 2003

Safety and Efficacy of intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures
Epilepsia 2003

inhaled Nitric Oxide for Acute Hypoxic Respiratory Failure in Children and Adults: A Meta-analysis
Anesth Analg 2003

Prone Positioning of Pediatric Patients With ARDS Results in Improvement in Oxygenation if Maintained > 12 h Daily
Chest 2003

Ventilator-Associated Pneumonia in intubated Children: Comparison of Different Diagnostic Methods
Pediatr Crit Care Med 2003

influence of Respiratory System Impedance on Volume and Pressure Delivered at the Y Piece in Ventilated infants
Pediatr Crit Care Med 2003

Carbon Dioxide Attenuates Pulmonary Impairment Resulting from Hyperventilation
Crit Care Med 2003

 

Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with induced Hypothermia
N Eng J Med 2002

Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest
N Eng J Med 2002

Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Patients in Septic Shock
Crit Care Med 2002

Effect of Treatment with Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients with Septic Shock
JAMA 2002

Corticosteroids for the Prevention of Reintubation and Postextubation Stridor in Pediatric Patients: A Meta-analysis
Pediatr Crit Care Med 2002

High-Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome in Adults: A Randomized Controlled Trial
Am J Respir Crit Care Med 2002

Accuracy of Displayed Values of Tidal Volume in the Pediatric intensive Care Unit
Crit Care Med 2002

Are Tidal Volume Measurements in Neonatal Pressure-Controlled Ventilation Accurate?
Pediatr Pulmonol 2002

Effect of Mechanical Ventilator Weaning Protocols on Respiratory Outcomes in infants and Children. A Randomized Controlled Trial.
JAMA 2002

 

intensive insulin Therapy in Critically Ill Patients
N Eng J Med 2001

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
N Eng J Med 2001

Feasibility of Tidal Volume-Guided Ventilation in Newborn infants: A Randomized, Crossover Trial Using the Volume Guarantee Modality
Pediatrics 2001

Lacrosse Encephalitis in Children
N Eng J Med 2001

Extubation Failure in a Large Pediatric ICU Population
Chest 2001

Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis
N Eng J Med 2001

 

Tidal Volumes for Ventilated infants Should Be Determined with a Pneumotachometer Placed at the Endotracheal Tube
AJRCCM 2000

Do Doctors Cause or Prevent Cerebral Edema in Children with Diabetic Ketoacidosis?
Pediatric Diabetes 2000

Ventilation with Low Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung injury and the Acute Respiratory Distress Syndrome
N Eng J Med 2000

Adverse Sedation Events in Pediatrics: A Critical incident Analysis of Contributing Factors
Pediatrics 2000

Use of Hypertonic Saline in the Treatment of Severe Refractory Posttraumatic intracranial Hypertension in Pediatric Traumatic Brain injury
Crit Care Med 2000

Corticosteroids for the Prevention and Treatment of Post-extubation Stridor in Neonates, Children and Adults
Cochrane Database Syst Rev 2000

Serial Blood Lactate Measurements Predict Early Outcome after Neonatal Repair or Palliation for Complex Congenital Heart Disease
J Thorac Cardiovasc Surg 2000

 

A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
N Eng J Med 1999

Clinically Significant Upper Gastrointestinal Bleeding Acquired in a Pediatric intensive Care Unit: A Prospective Study
Pediatrics 1998

Benefit of Heparin in Peripheral Venous and Arterial Catheters: Systematic Review and Meta-analysis of Randomised Controlled Trials
BMJ 1998

Elevation of Systemic Oxygen Delivery in the Treatment of Critically Ill Patients
N Eng J Med 1994

Effects of Bicarbonate Therapy on Hemodynamics and Tissue Oxygenation in Patients with Lactic Acidosis: A Prospective, Controlled Clinical Study
Crit Care Med 1991

Bicarbonate does not Improve Hemodynamics in Critically Ill Patients who Have Lactic Acidosis: A Prospective, Controlled Clinical Study
Ann intern Med 1990